Thermo Fisher Scientific Rubicon Polyclonal Antibody
Rubicon 단백질을 인식하는 Thermo Fisher Scientific의 다클론성 항체로, Western blot 및 Immunoprecipitation에 적합. 인간 시료 반응성이 높으며, 항원 친화 크로마토그래피로 정제됨. 장기 보관 시 -20°C에서 안정적으로 유지.
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Thermo Fisher Scientific Rubicon Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:20,000
- Immunoprecipitation (IP): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 677–972 of Rubicon |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| RRID | AB_2553279 |
Product Specific Information
- Recommended positive controls: MDA-MB-231, NT2D1, human Rubicon-transfected 293T
- Predicted reactivity: Mouse (92%), Pig (94%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly before opening the vial.
Target Information
Rubicon (RUN domain Beclin-1 interacting and cysteine-rich containing protein) interacts with Beclin-1 and ATG14L to regulate autophagy.
Knockdown of Rubicon enhances autophagy, whereas knockdown of ATG14L impairs autophagosome formation.
Rubicon functions as part of a Beclin-1–PIK3C3-containing autophagy complex and positively regulates the NADPH oxidase complex.
Upon microbial infection or TLR2 activation, Rubicon interacts with CYBA subunit of NADPH oxidase, inducing reactive oxygen species and inflammatory cytokine production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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