Thermo Fisher Scientific LDLR Monoclonal Antibody (OTI7C5), TrueMAB
LDLR 단백질을 타깃으로 하는 Mouse IgG1 단일클론 항체로, Western blot과 Flow cytometry에 최적화됨. HEK293T 세포에서 생산된 인간 LDLR 재조합 단백질을 면역원으로 사용. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7C5 |
| Immunogen | Full length human recombinant protein of human LDLR produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell, ending up in lysosomes where the protein is degraded and cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase—the rate-limiting step in cholesterol synthesis. A reciprocal stimulation of cholesterol ester synthesis also occurs.
Mutations in the LDL-R gene cause the autosomal dominant disorder familial hypercholesterolemia. Along with SCARB1, CLDN1, and CD81, LDL-R has been reported to act as an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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