Thermo Fisher Scientific TIM-4 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal TIM-4 항체로 WB, IHC, ICC/IF에 사용 가능. 합성 펩타이드 면역원 기반으로 제작되었으며, 액상 형태로 1 mg/mL 농도 제공. PBS + 50% glycerol 보존액에 0.02% sodium azide 포함, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TIMD4 (Accession Q96H15), corresponding to amino acid residues S272–S322 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900679 |
Product Specific Information
Antibody detects endogenous levels of total TIM-4.
Target Information
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in regulation of T helper (Th)1 and Th2 cell-mediated immunity. TIM-4, preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, leading to T-cell expansion and cytokine production. Unlike other TIM family members, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans, and due to its connection to TIM-1-triggered Th2 responsiveness, may be considered a candidate gene for asthma susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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