Thermo Fisher Scientific CD16a/CD16b Polyclonal Antibody
CD16a/CD16b를 인식하는 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성. WB, IHC, ICC, Flow, ELISA 등 다양한 응용 가능. Protein A 정제, 1 mg/mL 농도, 안정한 액상 형태로 연구용 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CD16a |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from circulation. It also plays roles in cellular mediated cytotoxicity and enhancement of virus infections.
The gene FCGR3A shares a high degree of similarity with FCGR3B, located on chromosome 1.
- FCGR3A: Expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide.
- FCGR3B: Expressed on polymorphonuclear neutrophils (PMN) with a phosphatidylinositol (PI) linkage.
Mutations in FCGR3A are associated with immunodeficiency 20 and linked to susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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