Thermo Fisher Scientific SIK2 Polyclonal Antibody
Thermo Fisher Scientific의 SIK2 Polyclonal Antibody는 인간 및 동물 시료에 반응하는 Rabbit IgG 기반 항체로, Western blot에 최적화되어 있습니다. SIK2 단백질의 100-150번 잔기 합성 펩타이드로 면역화되었으며, 고순도 Protein G 정제 및 안정적 PBS 버퍼로 제공됩니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1–3 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 100–150 of human SIK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2285877 |
Product Specific Information
- Suggested positive control: human brain tissue, human brain protein.
Target Information
SNF1LK2 (QIK) is a serine/threonine kinase and a salt-inducible kinase belonging to the AMP-activated protein kinase family.
SIK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator TORC.
It is involved in signaling cascades regulating insulin-induced genes (PGC-1α, UCP-1) in brown adipocytes, with implications in obesity and insulin resistance.
SIK2 also acts as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression following oxygen-glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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