Thermo Fisher Scientific RNAse H2A Polyclonal Antibody
Thermo Fisher Scientific의 RNAse H2A Polyclonal Antibody는 인간 RNAse H2A 중심 영역의 재조합 단백질을 항원으로 제작된 비결합형 토끼 IgG 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, AGS 관련 연구에 활용됩니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: View 2 publications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- Publications: View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human RNAse H2A (proprietary sequence) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.82 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736528 |
Product Specific Information
- Positive Control: HeLa, HeLa NE
- Predicted Reactivity: Mouse (88%), Rat (85%), Pig (90%), Bovine (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. Their major role is to remove the RNA strand from RNA/DNA hybrids formed during DNA replication and repair. RNAse H2 consists of three subunits, all required for enzymatic activity. Mutations in RNAse H2A or other subunits are associated with Aicardi-Goutieres syndrome (AGS), a neurological disorder resembling viral brain infections, characterized by elevated IFN-alpha levels in cerebrospinal fluid. Similar conditions occur with TREX1 mutations, suggesting overlapping roles in nucleic acid metabolism and innate immune activation.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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