Thermo Fisher Scientific TAOK1 Polyclonal Antibody
TAOK1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간에서 반응하며, 마우스·랫·Xenopus에서도 예측 반응합니다. 액상 형태로 1.5 mg/mL 농도이며, PBS(pH 7.4) 내 0.09% sodium azide를 포함합니다. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
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Applications
Tested Application
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 620–650 from the central region of human TAOK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2271457 |
Product Specific Information
This antibody is predicted to react with mouse, rat, and Xenopus based on sequence homology.
Target Information
TAOK1 (Thousand and One Amino Acid Kinase 1) is a serine/threonine-protein kinase involved in regulating the p38-containing stress-responsive MAP kinase and ERK kinase (MEK) pathways.
It activates MEK3, linking TAOK1 to the regulation of the p38 MAPK cascade.
Also known as MARKK (Microtubule Affinity-Regulating Kinase Kinase), TAOK1 plays key roles in mitotic progression, chromosome congression, and checkpoint-induced anaphase delay.
TAOK1 participates in processes such as stress-activated MAPK signaling, DNA damage response, and cytoskeleton stability regulation.
It phosphorylates MAP2K3, MAP2K6, and MARK2, acting as an activator of the p38/MAPK cascade and contributing to G-protein–coupled receptor signaling to p38/MAPK14.
In response to DNA damage, TAOK1 mediates the G2/M transition checkpoint through MAP2K3 and MAP2K6 phosphorylation, regulating apoptosis and cytoskeletal integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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