Thermo Fisher Scientific TAOK1 Polyclonal Antibody

Applications

Tested Application

• Western Blot (WB): 1:1,000 dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse, rat, and Xenopus based on sequence homology.

Target Information

TAOK1 (Thousand and One Amino Acid Kinase 1) is a serine/threonine-protein kinase involved in regulating the p38-containing stress-responsive MAP kinase and ERK kinase (MEK) pathways.
It activates MEK3, linking TAOK1 to the regulation of the p38 MAPK cascade.
Also known as MARKK (Microtubule Affinity-Regulating Kinase Kinase), TAOK1 plays key roles in mitotic progression, chromosome congression, and checkpoint-induced anaphase delay.
TAOK1 participates in processes such as stress-activated MAPK signaling, DNA damage response, and cytoskeleton stability regulation.
It phosphorylates MAP2K3, MAP2K6, and MARK2, acting as an activator of the p38/MAPK cascade and contributing to G-protein–coupled receptor signaling to p38/MAPK14.
In response to DNA damage, TAOK1 mediates the G2/M transition checkpoint through MAP2K3 and MAP2K6 phosphorylation, regulating apoptosis and cytoskeletal integrity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.