Thermo Fisher Scientific ARHGEF1 Polyclonal Antibody
ARHGEF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, Human 시료 반응성. 연구용으로만 사용, 진단용 불가.
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- PA584467
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARHGEF1. Recombinant protein control fragment (Product #RP-105157) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791618 |
Product Specific Information
Immunogen sequence:
LRVPVPPNVA FELDRTRADL ISEDVQRRFV QEVVQSQQVA VGRQLEDFRS KRLMGMTPWE QELAQLEAWV GRDRASYEAR ERHVAERLLM HLEEMQHTIS TDEEKSAAVV NAIGL
Target Information
The Ras superfamily of GTPases, subdivided into Ras, Rho/Rac, Sar, Rab, ARF, and Ran subfamilies, regulates various cellular functions such as cytoskeletal rearrangement, nuclear signaling, and cell growth. These GTPases act as molecular switches toggling between active (GTP-bound) and inactive (GDP-bound) states, with activation catalyzed by guanine nucleotide exchange factors (GEFs).
Dbl-related proteins form a large family capable of catalyzing GEF activity for specific Ras family members, including FGD1, Lsc, RhoGEF p115, Lfc, Lbc, and Brx. Lsc, Lbc, and Lfc share sequence homology and exhibit exchange activity toward Rho family GTPases. RhoGEF p115 catalyzes GEF activity for Rho but not Rac, Cdc42, or Ras GTPases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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