Thermo Fisher Scientific PD-L1 Recombinant Rabbit Monoclonal Antibody (10D4)
PD-L1 단백질을 표적으로 하는 토끼 유래 재조합 단클론 항체. Western blot 및 IHC(P)에서 검증됨. 높은 특이성과 재현성을 제공하며, 인간 시료에 반응. 액상 형태로 제공되며, 장기 보관 시 -20°C 이하에서 안정적 유지.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10D4 |
| Immunogen | A synthesized peptide derived from human PD-L1 (CD274) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS (pH 7.4), with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898333 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1 — the programmed death receptor 1 (PD-1). PD-1 negatively regulates T-cell receptor (TCR) signaling. Upon ligation, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be further up-regulated upon IFN-gamma stimulation, suggesting a key role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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