Thermo Fisher Scientific LGR5 Monoclonal Antibody (OTI2A2)
LGR5 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, WB, IHC, ICC, Flow, IP 등 다양한 응용에 적합합니다. Human 및 Mouse 시료에 반응하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | - | 5 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | 5 publications |
| Flow Cytometry (Flow) | 1:100 | - |
| Immunoprecipitation (IP) | 2 µg / 500 µL | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 250–550 of LGR5 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723318 |
Target Information
G protein-coupled receptor GPR49 (also known as LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from human germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, with over a thousand predicted members. All GPCRs share a seven-transmembrane helical structure and exist in active and inactive forms. Ligand binding induces conformational changes leading to G-protein signaling and downstream effects. Negative regulation mechanisms of GPCRs are crucial for cellular physiology and are key targets for pharmacological research. Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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