Thermo Fisher Scientific IL-22 Receptor alpha Polyclonal Antibody
Human IL-22 Receptor alpha를 인식하는 Goat Polyclonal Antibody로, IHC(P) 및 ELISA에 적합. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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- PA121361
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:300 |
| ELISA | 1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide of Human IL22 Receptor N terminal amino acids 42–70 (DSGPEGTPDTVYSIEYKTYGERDWVAKK) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 10 mM potassium phosphate with 140 mM NaCl, 1 mg/mL BSA |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_559651 |
Product Specific Information
Recommended positive controls: Human spleen or tonsil.
Target Information
A novel cytokine, designated IL-TIF (IL-10 related T cell-derived inducible factor) or IL-22, was recently identified.
The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) belongs to the class II cytokine receptor family.
IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling through the JAK-STAT pathway.
IL22R is expressed in normal liver and kidney tissues and in their cell lines (HepG2 and TK-10).
A soluble form of IL-22 receptor, IL-22 binding protein (IL-22BP, IL-22RA2), prevents IL-22 from binding to the functional IL-22R complex, neutralizing IL-22 activity.
LPS induces IL-22 expression, indicating its role in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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