Thermo Fisher Scientific IRF7 Polyclonal Antibody
IRF7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat에 반응하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며, -20°C에서 안정적으로 저장 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IRF7 (Accession Q92985), corresponding to amino acid residues S447–M497 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852222 |
Product Specific Information
Antibody detects endogenous levels of total IRF7.
Target Information
Interferons (IFNs) are involved in numerous immune interactions during viral infections and play a crucial role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions activate downstream molecules such as transcription factors like IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes. IRF7 is involved in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. It plays a major role in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, though their functions have not been clearly established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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