Thermo Fisher Scientific NR3C1 Monoclonal Antibody (OTI7A3), TrueMAB

Applications

Tested Dilution

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Glucocorticoid Receptor (NR3C1) acts as both a transcription factor and a regulator of other transcription factors. It forms heteromeric cytoplasmic complexes with heat shock factors and immunophilins. Upon ligand binding, it translocates into the nucleus.
NR3C1 is expressed in various heart tissues including atria, ventricles, aorta, apex, septum, and atrioventricular node, as well as in fetal heart.
Alternative splicing and promoter usage lead to multiple transcript variants and isoforms. Mutations in NR3C1 are linked to glucocorticoid resistance.
GR must associate with chaperone protein complexes for ligand activation and binds steroids such as dexamethasone with nanomolar affinity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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