Thermo Fisher Scientific Phospho-EGFR (Tyr1068) Recombinant Rabbit Monoclonal Antibody (EGFRY1068-E5), FITC
FITC 형광 표지된 Phospho-EGFR (Tyr1068) 재조합 토끼 단클론 항체로, 인간·마우스·랫트 시료에 반응합니다. Flow Cytometry에 최적화되어 있으며, 높은 특이성과 일관된 로트 간 재현성을 제공합니다. 단백질 A/G 정제, 4°C 암소 보관.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | EGFRY1068-E5 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896902 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone the specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression is associated with multiple cancers and serves as a target for biological and small-molecule therapeutics.
EGFR is encoded by the EGFR gene on chromosome 7 and belongs to the HER/ERbB family (ERbB2, ERbB3, ERbB4). Ligand binding (e.g., EGF, TGFα) induces receptor dimerization and autophosphorylation of tyrosine residues.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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