Thermo Fisher Scientific HERPUD1 Monoclonal Antibody (OTI1A2)
HERPUD1 단백질 검출용 Thermo Fisher Scientific의 마우스 단일클론 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 인간 및 랫트 반응성, 액상 형태로 안정적 보관 가능. 연구용으로만 사용.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400–1:4,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A2 |
| Immunogen | Full length human recombinant protein of HERPUD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724440 |
Target Information
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes inhibition of translation to prevent further accumulation of unfolded proteins, increased expression of proteins involved in polypeptide folding (unfolded protein response, UPR), and destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system.
HERPUD1 may play roles in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region. The encoded protein has an N-terminal ubiquitin-like domain that may interact with the ERAD system. It interacts with presenilin proteins and may increase amyloid-beta levels when overexpressed.
Alternative splicing produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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