ELK Biotechnology Fibulin-4 rabbit pAb
Fibulin-4 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 EFEMP2 유래 펩타이드로 면역화됨. 탄성섬유 형성과 결합조직 발달 연구에 적합. Human, Rat, Mouse 반응성.
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제품명
Fibulin-4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EFEMP2; FBLN4; EGF-containing fibulin-like extracellular matrix protein 2; Fibulin-4; FIBL-4; Protein UPH1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human EFEMP2 (AA range: 91-140) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 30008 |
| Human Swiss-Prot No. | O95967 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Secreted, extracellular space, extracellular matrix, basement membrane. Localizes on the microfibrils surrounding ELN cores. |
Background
A large number of extracellular matrix proteins contain variations of the epidermal growth factor (EGF) domain and are implicated in functions such as blood coagulation, complement activation, and cell fate determination during development. The protein encoded by this gene includes four EGF2 domains and six calcium-binding EGF2 domains. It is essential for elastic fiber formation and connective tissue development. Defects in this gene cause an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene. (RefSeq, Jan 2011)
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