ELK Biotechnology NMDAε1/2 (phospho Tyr1246/1252) rabbit pAb
NMDAε1/2 인산화 타이로신(Tyr1246/1252)을 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능. 인간 NMDAR2A/B 유래 합성 펩타이드로 면역화. 시냅스 및 수상돌기막 발현 연구에 적합. -20°C 보관.
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제품명
NMDAε1/2 (phospho Tyr1246/1252) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human NMDAR2A/B around the phosphorylation site of Tyr1246/1252 (AA range: 1216–1265) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 2903 / 2904 |
| Human Swiss-Prot No. | Q12879 / Q13224 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell projection, dendritic spine; Cell membrane (multi-pass membrane protein); Cell junction, synapse; Postsynaptic cell membrane; Cytoplasmic vesicle membrane. Expression at dendrite cell membrane and synapses is regulated by SORCS2 and the retromer complex. |
Background
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. (RefSeq, May 2014)
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