ELK Biotechnology GluR4 (phospho Ser862) rabbit pAb
GluR4 (phospho Ser862) rabbit pAb는 AMPA형 글루탐산 수용체의 인산화 형태를 검출하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 사용 가능하며 인간, 생쥐, 랫트 반응성을 가집니다. 고순도 IgG로 신경생리학 연구에 적합합니다.
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- ES5637-xxxxx (2개 옵션)
- 판매단위
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GluR4 (phospho Ser862) rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | GluR4 (phospho Ser862) rabbit pAb |
| Alternative Names | GRIA4; GLUR4; Glutamate receptor 4; GluR-4; GluR4; AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic; AMPA 4; GluA4 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human GluR4 around the phosphorylation site of Ser862 (AA range: 828–877) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kD |
| GeneID (Human) | 2893 |
| Human Swiss-Prot No | P48058 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cell membrane; Multi-pass membrane protein.
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Cell projection, dendrite.
Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression.
배경 (Background)
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists.
The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA→GGA; R→G).
Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
[provided by RefSeq, Jul 2008]
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