ELK Biotechnology Kpm rabbit pAb
인간 LATS2 유래 펩타이드에 대한 rabbit polyclonal antibody. IHC, IF, ELISA에 적합하며 세포골격 및 중심체에 위치. p53 관련 세포주기 조절 연구에 활용 가능. -20°C에서 1년 보관.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Kpm rabbit pAb
제품명
Kpm rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Kpm rabbit polyclonal antibody는 인간 LATS2 단백질을 인식하는 항체로, 세포골격 및 중심체에서 발현되는 LATS 종양 억제 단백질 연구에 적합합니다. IHC, IF, ELISA 등 다양한 응용 분야에서 사용 가능합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Alternative Names | LATS2; KPM; Serine/threonine-protein kinase LATS2; Kinase phosphorylated during mitosis protein; Large tumor suppressor homolog 2; Serine/threonine-protein kinase kpm; Warts-like kinase |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human LATS2 (AA range: 541–590) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 26524 |
| Human Swiss-Prot No | Q9NRM7 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, spindle pole, nucleus.
Colocalizes with AURKA at the centrosomes during interphase, early prophase, and cytokinesis.
Migrates to spindle poles during mitosis and to the midbody during cytokinesis.
Translocates to the nucleus upon mitotic stress (nocodazole treatment).
Background
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase and metaphase, interacts with aurora-A and ajuba, and is required for gamma-tubulin accumulation and spindle formation at mitosis onset. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 responding to cytoskeleton damage. Additionally, it can act as a co-repressor of androgen-responsive gene expression.
[Provided by RefSeq, Jul 2008]
제품 이미지
(이미지 없음)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.