Thermo Fisher Scientific Bora Polyclonal Antibody
Thermo Fisher Scientific의 Bora Polyclonal Antibody는 인간, 마우스, 랫트 반응성을 가진 Rabbit IgG 항체로, WB, IHC, ICC/IF에 사용됩니다. 액상 형태이며 항원 친화 크로마토그래피로 정제되었습니다. 세포 주기 조절 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the amino terminus of human Bora |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153509 |
Product Specific Information
A suggested positive control is Jurkat cell lysate.
PA5-20709 can be used with blocking peptide PEP-0824.
Target Information
Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly, and chromosome segregation during mitosis.
Bora localizes to the nucleus until mitosis begins, then translocates to the cytoplasm in a Cdc2-dependent manner. Activation of Cdc2 releases Bora into the cytoplasm, where it binds and activates ARK-1.
PLK1 (polo-like kinase-1) interacts with Bora to control phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 to control mitotic entry.
Mutations in Bora result in multipolar spindles similar to those observed when ARK-1 function is blocked, highlighting the ARK1–Bora–PLK1 regulatory circuit as a key mechanism in cell cycle regulation.
At least three isoforms of Bora are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 정보: PA5-20709_Bora_Q6PGQ7-1_Rabbit_PDP.jpeg, PA5-20709_Bora_Q6PGQ7-1_Rabbit.svg)
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