Thermo Fisher Scientific Cystatin M Polyclonal Antibody
Human Cystatin M을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:500~1:1,000 희석 비율로 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 buffer에 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific Cystatin M Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Cystatin M (Product #RP-95143) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640345 |
Product Specific Information
Immunogen sequence:
SNSIYYFRDT HIIKAQSQLV AGIKYFLTME MGSTDCRKTR VTGDHVDLTT CPLAAGAQQE KLRCDFEVLV VPWQNSSQLL KH
Highest antigen sequence identity to the following orthologs:
- Mouse: 72%
- Rat: 74%
Target Information
The cystatin superfamily is a well-established family of cysteine protease inhibitors.
- Type 1 cystatins (A and B): mainly intracellular
- Type 2 cystatins (C, D, E/M, F, G, S, SN, SA): extracellular
- Type 3 cystatins (kininogens): intravascular proteins
All true cystatins inhibit cysteine peptidases of the papain family (e.g., cathepsins) and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are found primarily in saliva, and also expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate cathepsin inhibition.
Fetuins, part of the cystatin superfamily, influence osteogenesis, bone resorption, insulin and hepatocyte growth factor receptor regulation, and systemic inflammation response.
High and low molecular weight kininogens inhibit thrombin- and plasmin-induced platelet aggregation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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