Thermo Fisher Scientific Cystatin M Polyclonal Antibody

Thermo Fisher Scientific Cystatin M Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000

Product Specifications

Product Specific Information

Immunogen sequence:
SNSIYYFRDT HIIKAQSQLV AGIKYFLTME MGSTDCRKTR VTGDHVDLTT CPLAAGAQQE KLRCDFEVLV VPWQNSSQLL KH

Highest antigen sequence identity to the following orthologs:

• Mouse: 72%
• Rat: 74%

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.

• Type 1 cystatins (A and B): mainly intracellular
• Type 2 cystatins (C, D, E/M, F, G, S, SN, SA): extracellular
• Type 3 cystatins (kininogens): intravascular proteins

All true cystatins inhibit cysteine peptidases of the papain family (e.g., cathepsins) and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are found primarily in saliva, and also expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate cathepsin inhibition.
Fetuins, part of the cystatin superfamily, influence osteogenesis, bone resorption, insulin and hepatocyte growth factor receptor regulation, and systemic inflammation response.
High and low molecular weight kininogens inhibit thrombin- and plasmin-induced platelet aggregation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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