Thermo Fisher Scientific ADAM10 Polyclonal Antibody
ADAM10 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 사용 가능. 인간 및 마우스 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%)이며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to residues in Human ADAM10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803537 |
Product Specific Information
Purity is greater than 95% by SDS-PAGE.
Target Information
Proinflammatory cytokine tumor necrosis factor-α (TNF-α) contributes to various inflammatory responses and programmed cell death. The Notch receptor and its ligand are involved in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma. TNF-α, Notch, and its ligand Delta are membrane-bound molecules that are cleaved by proteases to release mature proteins or functional receptors.
ADAM10, a metalloprotease-disintegrin in the ADAM family (a disintegrin and metalloprotease), has been identified to cleave TNF-α, Notch, and Delta. The genes encoding human, mouse, and bovine ADAM10 were cloned and designated ADAM10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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