Thermo Fisher Scientific CUEDC2 Polyclonal Antibody
Recombinant Human CUEDC2 항원을 면역원으로 한 Rabbit Polyclonal Antibody. ICC/IF에 0.25–2 µg/mL 농도로 사용 가능. Human 반응성, 항원 친화 크로마토그래피로 정제. PBS/glycerol buffer, 4°C 보관 권장.
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Applications
Immunocytochemistry (ICC/IF)
- Tested dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human CUEDC2. Recombinant protein control fragment (Product #RP-106018) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2664749 |
Product Specific Information
Immunogen sequence:
QKDELKSFILQ KYMMVDSAED QKIHRPMAPK EAPKKLIRYI DNQVVSTKGE RFKDVRNPEA EEMKATYINL KPARKYRFH
- Highest antigen sequence identity to orthologs: mouse 96%, rat 94%
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.
CUEDC2 (CUE domain-containing protein 2) was identified through yeast two-hybrid screening as a protein interacting with the progesterone receptor (PR), promoting progesterone-induced PR degradation via the ubiquitin-proteasome pathway.
CUEDC2 also decreases PR sumoylation and interacts with IKK-alpha and IKK-beta, reducing NF-kappa-B activation by decreasing IKK activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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