Thermo Fisher Scientific PAICS Monoclonal Antibody (OTI1B4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes a bifunctional enzyme containing:

• Phosphoribosylaminoimidazole carboxylase activity (N-terminal region)
• Phosphoribosylaminoimidazole succinocarboxamide synthetase activity (C-terminal region)

It catalyzes steps 6 and 7 of purine biosynthesis.
The gene is closely linked and divergently transcribed with another locus in the same pathway, and transcription of the two genes is coordinately regulated.
The human genome contains several pseudogenes of this gene, and multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.