Thermo Fisher Scientific COP1/RFWD2 Polyclonal Antibody
Rabbit polyclonal antibody against human COP1/RFWD2 (residues 1–50). Validated for Western blot and immunoprecipitation. Unconjugated, liquid form, 1 mg/mL concentration. For research use only; not for diagnostic applications.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human Constitutive Photomorphogenic Protein-1 / Ring Finger and WD Repeat Domain 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Involved in JUN ubiquitination and degradation.
Directly involved in p53 (TP53) ubiquitination and degradation, abolishing p53-dependent transcription and apoptosis.
Ubiquitinates p53 independently of MDM2 or RCHY1.
Functions as the essential RING domain subunit of larger E3 complexes.
Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival.
Ubiquitinates MTA1 leading to its proteasomal degradation.
Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif.
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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