Thermo Fisher Scientific ECSIT Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human ECSIT.

Target Information

Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88 to kinases like IRAK and intermediates such as TNF receptor associated factor (TRAF)-6.
ECSIT (Evolutionarily Conserved Signaling Intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TRAF-6 in the TLR pathway.
Recently, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, suggesting possible cross-talk between TLR/IL-B and Bmp signaling pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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