Thermo Fisher Scientific ECSIT Polyclonal Antibody
Human ECSIT 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ELISA에 적합합니다. 보존제가 없는 액상 형태이며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. NF-kappa-B 및 TLR 신호 전달 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10,000–1:50,000 |
| ELISA | 1:25,000–1:50,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ECSIT protein (Glu246–Ser431) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787869 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human ECSIT.
Target Information
Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88 to kinases like IRAK and intermediates such as TNF receptor associated factor (TRAF)-6.
ECSIT (Evolutionarily Conserved Signaling Intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TRAF-6 in the TLR pathway.
Recently, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, suggesting possible cross-talk between TLR/IL-B and Bmp signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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