Thermo Fisher Scientific TWEAK Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TWEAK. Recombinant protein control fragment (Product #RP-104485). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TWEAK,uniProtId:O43508-1,ncbiNodeId:9606,antigenRange:53-165,antigenLength:249,antigenImageFileName:PA5-62711_TWEAK_O43508-1_Rabbit.svg,antigenImageFileNamePDP:PA5-62711_TWEAK_O43508-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649127

Product Specific Information

Immunogen sequence: QEPAQEELVA EEDQDPSELN PQTEESQDPA PFLNRLVRPR RSAPKGRKTR ARRAIAAHYE VHPRPGQDGA QAGVDGTVSG WEEARINSSS PLRYNRQIGE FIVTRAGLYY LYC

Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 81%.

Target Information

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.