Thermo Fisher Scientific SST3, Somatostatin Receptor 3 Polyclonal Antibody

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Product Specifications

Target Information

Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms.

An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors.
Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs.
This “turn-off” activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates.

Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have multi-billion dollar shares of the mental health and allergy markets, respectively.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.