Thermo Fisher Scientific Aromatase Polyclonal Antibody
Aromatase 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합. Human, Mouse 등 여러 종에 반응하며 항원 친화 크로마토그래피로 정제됨. 1.0 mg/mL 농도의 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rabbit, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide made to a C-terminal portion of the human aromatase protein sequence (between residues 400–502). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_568446 |
Product Specific Information
This antibody is expected to react with equine (91%), bovine and rabbit (90%), porcine (83%), ovine, goat and canine (81%) based on sequence homology.
Suggested positive control: Antigen standard for CYP19A1 (transient overexpression lysate), human Fetal Temporal Lobe protein.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, performing three successive hydroxylations of the A ring of androgens.
Mutations in this gene can result in either increased or decreased aromatase activity, suggesting that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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