Thermo Fisher Scientific SIM2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human SIM2 protein. Suitable for research use in neurogenesis and Down syndrome studies. Supplied as liquid, 0.1 mg/mL concentration. Store at 4°C short term or -20°C long term. RRID: AB_2647308.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SIM2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2647308 |
Product Specific Information
Immunogen sequence:
CIVSVNYVLT EIEYKELQLS LEQVSTAKSQ DSWRTALSTS QETRKLVKPK NTKMKTKLRT NPYPPQQYSS FQMDKLECGQ LGNWRASPPA SAAAPPELQP HSESSDLLYT PSYSLPFSYH YGHFPLDSHV FSSKKPMLPA KFGQP
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 85%
Target Information
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the Down syndrome chromosomal region and is thought to contribute to specific Down syndrome phenotypes. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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