Thermo Fisher Scientific Synuclein alpha Polyclonal Antibody
Human과 Rat에서 반응하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin)에 적합. 알파 시뉴클레인 단백질 검출용. 항원 친화 크로마토그래피로 정제된 액상 형태. 파킨슨병 및 알츠하이머 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus of human alpha-Synuclein (UniProt ID: P37840-1, antigen range: 140 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human Normal Cerebral Cortex
- Cellular Location: Cytoplasm, cytosol, membrane, nucleus, cell junction
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are implicated in Parkinson’s disease. Alpha-synuclein peptides are also major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Lewy Body Dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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