Thermo Fisher Scientific PPP1R8 Monoclonal Antibody (OTI5H9), TrueMAB
인간 PPP1R8 단백질(aa 1-225)을 항원으로 제작된 Mouse IgG1 단클론 항체. IHC(P)에서 1:150 희석 사용 가능. 동결건조 형태로 제공되며, PBS/trehalose buffer 포함. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–225 of human PPP1R8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The PPP1R8 gene encodes three isoforms through alternative splicing.
- Two isoforms are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA.
- The third isoform lacks phosphatase inhibitory function but acts as a single-strand endoribonuclease similar to RNase E of E. coli.
- This isoform requires magnesium for activity and cleaves specific sites in A+U-rich RNA regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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