Thermo Fisher Scientific PPP1R8 Monoclonal Antibody (OTI5H9), TrueMAB

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The PPP1R8 gene encodes three isoforms through alternative splicing.

• Two isoforms are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA.
• The third isoform lacks phosphatase inhibitory function but acts as a single-strand endoribonuclease similar to RNase E of E. coli.
• This isoform requires magnesium for activity and cleaves specific sites in A+U-rich RNA regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.