Thermo Fisher Scientific SCNN1B Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Sodium-permeable, non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium (and osmotically following water) through the apical membrane of epithelial cells. Controls sodium reabsorption in kidney, colon, lung, and sweat glands, and also plays a role in taste perception.

The channel is a heterotetramer composed of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1, and WWP2.

Defects in SCNN1B are associated with:

• Autosomal recessive pseudohypoaldosteronism type 1 (PHA1) — a severe salt-wasting disease due to unresponsiveness to mineralocorticoids.
• Liddle syndrome — an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension with hypokalemic alkalosis.

Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.