Thermo Fisher Scientific PKNOX2 Polyclonal Antibody
PKNOX2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, 인간 시료에 반응합니다. ICC/IF에 적합하며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 4°C 단기 보관 및 -20°C 장기 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PKNOX2. Recombinant protein control fragment (Product #RP-105798) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664427 |
Product Specific Information
Immunogen sequence:
LEKVNELCKDF CNRYITCLKT KMHSDNLLRN DLGGPYSPNQ PSINLHSQDL LQNSPNSMSG VSNNPQGIVV PASALQQGNI AMTTVNSQVV SGGA
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family.
PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1, but displays a more restricted tissue distribution and a higher DNA-dissociation rate.
Like PREP-1, PREP-2 forms a heterodimer with Pbx1. The PREP-2–Pbx1 dimer is relocated to the nucleus where it associates with HoxB1 to form a ternary complex.
In contrast with PREP-1, which acts to increase transcriptional activation in this ternary complex, PREP-2 leads to a slight decrease in transcriptional activity.
Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin, and tubulin/microtubules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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