Thermo Fisher Scientific NOTCH2 Polyclonal Antibody

Thermo Fisher Scientific NOTCH2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant rat Notch-1 is observed, and less than 1% cross-reactivity with recombinant mouse Notch-3.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein.
NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain with diverse domain types.
It functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and associated cardiac, skeletal, and ophthalmologic manifestations.
Facial features are characteristic, with occasional renal and vascular system involvement.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.