Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
Rat NOTCH2 단백질을 인식하는 Goat Polyclonal Antibody로, Western Blot, IHC, Flow Cytometry 등에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 trehalose buffer에 보존. 연구용으로만 사용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–15 µg/mL | - |
| Flow Cytometry (Flow) | 2.5 µg per million cells | - |
| Neutralization (Neu) | Assay-Dependent | - |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Rat |
| Published Species | Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant rat Notch-2 (Leu26–Glu492) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576813 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant rat Notch-1 is observed, and less than 1% cross-reactivity with recombinant mouse Notch-3.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein.
NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain with diverse domain types.
It functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and associated cardiac, skeletal, and ophthalmologic manifestations.
Facial features are characteristic, with occasional renal and vascular system involvement.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.