Thermo Fisher Scientific NALP12 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction.
NALP12 (also known as Monarch-1) contains a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD), a NACHT domain, and a NACHT-associated domain.
NALP12 is believed to act as an attenuating factor of inflammation by suppressing NF-kappa-B activation via TLR-signaling molecules such as MyD88, IRAK-1, TRAF6, and RIPK1 in activated monocytes.
Mutations in NALP12 are associated with hereditary periodic fever syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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