Thermo Fisher Scientific Cullin 9 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Cullin 9. Validated for ICC/IF with high specificity. Supplied as a liquid, unconjugated form in PBS with glycerol. Ideal for research on p53 regulation and ubiquitin ligase pathways.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Cullin 9. Recombinant protein control fragment (Product # RP-106368) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663968 |
Product Specific Information
Immunogen sequence:
WKPNHKDYYNC SAMVSKAARQ EKRFQDYNER CTFHHQAREF AVNLRNRVSA IHEVPPPRSF TFLNDACQGL EQARKVLAYA CVYSFYSQDA EYMDVVEQQT ENLELHT
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 92%
Target Information
The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large Parkin-like ubiquitin ligase, has been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression promotes cytoplasmic sequestration of p53. PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the cullin family of E3 ubiquitin ligases, may perform similar functions. It has also been suggested that p53 binding to PARC may serve to control PARC function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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