Thermo Fisher Scientific CACNG1 (extracellular) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:400

-

Immunohistochemistry (Paraffin) (IHC (P))

1:100

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide (C)DHWAVLSPHLEHHNE, corresponding to amino acid residues 30-44 of rat Cavgamma1 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CACNG1,uniProtId:P97707-1,ncbiNodeId:10114,antigenRange:30-44,antigenLength:223,antigenImageFileName:PA5-77347_CACNG1_P97707-1_Rabbit.svg,antigenImageFileNamePDP:PA5-77347_CACNG1_P97707-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2735554

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.

Target Information

Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an alpha1 subunit, a beta subunit, a gamma subunit and an alpha2 delta subunit. The beta subunit is encoded by four genes, designated beta1-beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the alpha1 subunit. L-type Ca ++ CP gamma1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP gamma1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP gamma1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anesthetics and depolarizing muscle relaxants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.