Thermo Fisher Scientific Phospho-IRAK4 (Thr345, Ser346) Polyclonal Antibody
Phospho-IRAK4 (Thr345, Ser346) 항체는 인간, 생쥐, 랫트에서 인산화된 IRAK4 단백질을 검출하는 Rabbit Polyclonal Antibody입니다. Western blot 및 IHC에 적합하며, NF-kappa-B 및 MAPK 신호 연구에 활용됩니다. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IRAK4 (Accession Q9NWZ3), corresponding to amino acid residues around phosphorylated Ser346 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815937 |
Product Specific Information
This antibody detects endogenous levels of IRAK4 only when phosphorylated at Thr345/Ser346.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK-4 activates NF-kappa-B and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses and in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-102849_IRAK4_Q9NWZ3-1_Rabbit.svg, PA5-102849_IRAK4_Q9NWZ3-1_Rabbit_PDP.jpeg)
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