Thermo Fisher Scientific SPRY1 Polyclonal Antibody
SPRY1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. 인간 및 생쥐에 반응하며, 비결합 액상 형태로 제공됩니다. 성장인자 신호 억제 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (IHC) | 1–3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (CPSRGQGKPS) corresponding to the C-terminus amino acids of SPRY1 (aa 310–319) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983542 |
Product Specific Information
This antibody is tested in Peptide ELISA with an antibody detection limit dilution of 16,000.
Target Information
Sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. Four mammalian Sprouty homologues (Sprouty-1–4) have been identified. Overexpression of Sprouty-1 and -2 inhibits fibroblast growth factor and vascular endothelial growth factor-induced proliferation and differentiation by repressing MAP kinase activation pathways.
Sprouty proteins act as endogenous inhibitors of the Ras/MAP kinase pathway, playing important roles in the remodeling of branching tissues such as the lung, kidney tubules, vascular system, and breast ducts.
Recent studies suggest Sprouty-1 and -2 may function as tumor suppressors in breast tissue, being consistently down-regulated in breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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