Thermo Fisher Scientific CDT1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-3 µg/mL

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (ARLAHQTRAEEGL) corresponding to the C-terminus amino acids of CDT1 (aa 534-546). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDT1,uniProtId:Q9H211-1,ncbiNodeId:9606,antigenRange:534-546,antigenLength:546,antigenImageFileName:PA5-18088_CDT1_Q9H211-1_Goat.svg,antigenImageFileNamePDP:PA5-18088_CDT1_Q9H211-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_10985522

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of Lys-4 of histone H3 (H3K4me) complex and acetylation of Lys-16 of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, and has higher activity toward H3 acetylated on Lys-9. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.