Thermo Fisher Scientific ORC1 Polyclonal Antibody
Human ORC1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ELISA에 적합합니다. 핵 내 ORC 복합체 연구에 활용되며, 고순도 Affinity Chromatography 정제 및 1.40 mg/mL 농도의 액상 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 696–856 of human ORC1 (NP_0011777481) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.40 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805894 |
Product Specific Information
- Immunogen sequence:
EDDAIQLVAR KVAALSGDAR RCLDICRRAT EICEFSQQKP DSPGLVTIAH SMEAVDEMFS SSYITAIKNS SVLEQSFLRA ILAEFRRSGL EEATFQQIYS QHVALCRMEG LPYPTMSETM AVCSHLGSCR LLLVEPSRND LLLRVRLNVS QDDVLYALKD E - Positive Samples: HeLa, 293T, A431, K562, Jurkat, MCF7, A549
- Cellular Location: Nucleus
Target Information
The origin recognition complex (ORC) is a highly conserved six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells. ORC binds specifically to origins of replication and serves as a platform for assembly of initiation factors such as Cdc6 and Mcm proteins. The ORC1 protein is the largest subunit of the complex, with levels varying during the cell cycle due to ubiquitin-mediated proteolysis after replication initiation. It is selectively phosphorylated during mitosis and interacts with MYST histone acetyltransferase 2 (MyST2/HBO1), involved in transcriptional silencing.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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