Thermo Fisher Scientific Sin1 Polyclonal Antibody
Sin1 단백질을 표적으로 하는 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. 인간 MAPKAP1 단백질 C-말단 영역(470–522)을 면역원으로 사용. 4°C 보관, 1년 권장 보관 기간. 다양한 종에서 교차 반응 예측됨.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 470 and the C-terminus (residue 522) of Human stress-activated map kinase interacting protein 1 (MAPKAP1, UniProt ID: Q9BPZ7-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
- Predicted to react with Mouse, Rat, Chicken, Sheep, Bovine, and Orangutan based on 100% sequence identity
Target Information
Sin1 was initially identified as the human homolog of S. pombe SIN1. It is identical to Mip1, a protein that interacts with MEKK2, a member of the MAPK intracellular signaling network. MAPKAP1 prevents MEKK2 activation and dimerization by forming a complex with inactive, non-phosphorylated MEKK2, thereby blocking JNK1/2, ERK1/2, p38, and ERK5 MAPKs.
MAPKAP1 also plays a role in the TOR signaling pathway, which regulates cell growth and proliferation in response to nutrients, growth factors, and hormones. It helps maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, enabling specific phosphorylation of Akt, linking growth factor–PI3K signaling to nutrient-regulated TOR signaling. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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