Thermo Fisher Scientific MBD1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MBD1 protein. Validated for Western blot at 2 µg/mL. Recognizes amino acids 98–113 and 391–405 of MBD1. Supplied as liquid, unconjugated, purified by Protein G. Suitable for research use in transcriptional rep...
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Applications
- Western Blot (WB): Tested dilution 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to amino acids 98–113 (RQVGPQSGEVRKEAPR) and 391–405 (SESEDGAGSPPPYRR) of human MBD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076605 |
Product Specific Information
- Suggested positive control: HeLa whole cell extract, HeLa cell lysate.
Target Information
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It functions as a transcriptional repressor by binding CpG islands in promoters where DNA is methylated at cytosine position 5 within CpG dinucleotides. Binding is abolished by 7-mG produced by DNA damage via methylmethanesulfonate (MMS).
MBD1 contributes to gene silencing by recruiting AFT7IP, which in turn recruits histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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