Thermo Fisher Scientific beta-2 Microglobulin VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1047)
베타-2 마이크로글로불린을 표적으로 하는 알파카 유래 재조합 단일클론 항체. ELISA, Flow Cytometry, SPR 등 다양한 어세이에 사용 가능. CHO 세포 발현, 금속 킬레이트 크로마토그래피로 정제. 연구용으로만 사용.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Surface Plasmon Resonance (SPR)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Alpaca / VHH |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SAA1047 |
| Immunogen | Recombinant Human B2M / Beta-2-microglobulin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Product Specific Information
- Compatible with Direct ELISA
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta-2 microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
Beta-2-microglobulin is also found in free form in plasma. Its amino acid sequence is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation.
Beta-2-microglobulin also plays a role in TCR signaling and downstream signaling in naive CD8+ cells. The B2M gene is located on chromosome 15, and mutations can lead to hypercatabolic hypoproteinemia. Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients and serve as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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