Thermo Fisher Scientific PIK3C2A Polyclonal Antibody
PIK3C2A 단백질을 인식하는 Thermo Fisher Scientific의 고품질 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등에 사용 가능하며, 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체로 연구용에 적합.
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Thermo Fisher Scientific PIK3C2A Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein of human PIK3C2A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803818 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enzymes have been linked to diverse receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking.
This protein contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of Class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs mediating translocation of proteins to membranes and protein-protein interactions.
The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. It can be activated by insulin and may be involved in integrin-dependent signaling.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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