Thermo Fisher Scientific Tau Monoclonal Antibody (BT2)

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin Conjugate
• Request custom conjugation

Product Specific Information

MN1010 recognizes normal Tau from human, rat, monkey, and bovine brain.
No cross-reactivity with PHF-Tau has been observed.
The epitope of this antibody has been mapped on human Tau between residues 194 and 198 (RSGYS sequence, Tau40 numbering).
MN1010 detects Tau with a predicted molecular weight of approximately 79 kDa.
This product is a Low Endotoxin formulation.
Purity is >95% as determined by SDS-PAGE.

Target Information

Tau is a neuronal microtubule-associated protein predominantly found on axons.
It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, functioning as a linker protein.
Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease.
Hyper-phosphorylation impairs Tau’s microtubule binding, leading to neuronal degeneration.
Kinases involved include GSK-3β, PKA, CDK5, and casein kinase II.
Abnormal Tau is also found in Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.