Thermo Fisher Scientific GBA Monoclonal Antibody (UMAB171), UltraMAB
Human GBA 단백질을 인식하는 Mouse IgG2a 단클론 항체로, IHC, ICC/IF, ChIP, Peptide Array 등에 사용 가능. Lyophilized 형태로 제공되며, 1 mg/mL 농도. Gaucher 병 관련 연구에 적합한 연구용 UltraMAB 제품.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 | |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | |
| ChIP assay (ChIP) | Assay-Dependent | |
| Peptide Array (Array) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB171 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 40–315 of human GBA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
GBA encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism.
Mutations in this gene cause Gaucher disease, a lysosomal storage disorder characterized by accumulation of glucocerebrosides.
A related pseudogene is located approximately 12 kb downstream on chromosome 1. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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