Thermo Fisher Scientific SIX5 Polyclonal Antibody
Human SIX5 단백질에 특이적인 Rabbit Polyclonal Antibody. IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체. 장기 보관 시 -20°C에서 보관 권장. 연구용 전용.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SIX5 Polyclonal Antibody
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SIX5. Recombinant protein control fragment (Product #RP-97611) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647322 |
Product Specific Information
Immunogen sequence:
VVPTSQVVTL PQAVGPLQLL AAGPGSPVKV AAAAGPANVH LINSGVGVTA LQLPSATAPG NFLLANPVSG SPIVTGVAVQ QGKIILTATF PTSMLVSQVL P
- Highest antigen sequence identity to the following orthologs:
- Mouse: 97%
- Rat: 90%
Target Information
Six5 (homeobox protein SIX5), also known as SIX5, BOR2, or DMAHP (DM locus-associated homeodomain protein), is a transcription factor expressed in various structures of the adult eye.
Localized to the cytoplasm in early development and to the nucleus in later stages, Six5 regulates organogenesis and maintains retinal formation.
It binds the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters, controlling transcription of associated mRNA.
Six5 is regulated via association with DACH1 and co-activated by EYA proteins.
Defects in the Six5 gene cause branchiooto-renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, deep overbite, and myopia.
Two isoforms exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.