Thermo Fisher Scientific CARD8 Polyclonal Antibody
Human CARD8 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 세포 사멸 및 NF-kappa-B 신호 연구에 활용 가능.
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Thermo Fisher Scientific CARD8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CARD8. Recombinant protein control fragment (Product #RP-98957). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639289 |
Product Specific Information
Immunogen sequence:
TLVWDTEVKP VDLQLVAASA PPPFSGAAFV KENHRQLQAR MGDLKGVLDD LQDNEVLTEN EKELVEQEKT RQSKNEALLS MVEKKGDLA
Antigen sequence identity:
- Mouse: 27%
- Rat: 31%
Target Information
Apoptosis is related to many diseases and developmental processes. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD-containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC.
CARD8 is a novel CARD-containing protein that interacts with DRAL, a p53-responsive protein implicated in apoptosis induction, as well as caspase-1 and its related proteins ICEBERG and pseudo-ICE. Although reports differ on whether CARD8 acts as a pro- or anti-apoptotic protein, it is suggested to function as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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